BRD 0476

CAS No. 1314958-91-2

BRD 0476 ( ML187 )

Catalog No. M11273 CAS No. 1314958-91-2

BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BRD 0476
  • Note
    Research use only, not for human use.
  • Brief Description
    BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X).
  • Description
    BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival; does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities, and the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476.
  • Synonyms
    ML187
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1314958-91-2
  • Formula Weight
    674.77
  • Molecular Formula
    C35H38N4O8S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=C2C=CC=CC2=CC=C1)NC3=C(O[C@@H](CN(S(=O)(C4=CC=C(OCCO5)C5=C4)=O)C)[C@H](C)CN([C@@H](C)CO)C6=O)C6=CC=C3
  • Chemical Name
    N-(((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-10-(3-(naphthalen-1-yl)ureido)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34.
2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702.
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